Abstract:
A group of degenerative inherited diseases which cause muscle weakness and loss of muscle tissue is called Muscular dystrophy. There are many types of muscular dystrophy. Duchenne muscular dystrophy  is fetal genetic mutation in 1 of every 3500 boys.This mutation can be diagnosed during child bearing( pregnancy) with the help of genetic studies. 

The patients of muscular dystrophy cannot produce protein called "Dystrophin" which keeps muscles strong. Boys feel problem in walking by 8 years of age. By their 19 they were on wheel chairs, and onward muscle function is so retarded that they die. If there is family history genetic counseling is advised.



Objective:
The main objective of this research was to improve the conditions of patients.Tivorsan Pharmaceuticals licensed rights from Brown University for the protein, biglycan, hope to prove potential therapy via clinical trials. Biglycan is a human protein,mainly found in tendons and bones.Biglycan in the presence of protein utrophin restore muscle strengthening.



Setting or Place:
Brown University in Rhode Island,United States.


Design:
This experiment was performed on mice who have similar genetic mutation as that of boys with muscular dystrophy. In experiments given in the paper, Fallon's team found that when they administered biglycan to the bloodstream, utrophin went into the cellular membranes of muscular cells. Utrophin protein help in building of cells and their strengthening.

Participants:
A group of Mice.

Results:
Mice treated with biglycan retain their muscular functions 50% more than untreated mice. The next big step is to test these results in humans.

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